منابع مشابه
Murine Heterotopic Heart Transplant Technique
It is now over forty years since this technique was first reported by Corry, Wynn and Russell. Although it took some years for other labs to become proficient in and utilize this technique, it is now widely used by many laboratories around the world. A significant refinement to the original technique was developed and reported in 2001 by Niimi. Described here are the techniques that have evolve...
متن کاملVarying Degrees of Ventricular Unloading in the Heterotopic Rat Heart Transplant Model Demonstrated by Magnetic Resonance Imaging
OBJECTIVE Left ventricular assist device placement is an increasingly common treatment for cardiac failure, resulting in cardiac unloading and potentially reversing the remodelling changes seen in heart failure. A popular animal model for human ventricular unloading is the rodent heterotopic non-working heart transplant; the volume loading status of this preparation is important to interpreting...
متن کاملHeterotopic Rat Model
Current organ preservation strategies subject graft vasculature to severe hypoxia (Po2 20 Torr), potentially compromising vascular function and limiting successful transplantation. Previous work has shown that cAMP modulates endothelial cell (EC) antithrombogenicity, barrier function, and leukocyte/EC interactions, and that hypoxia suppresses EC cAMP levels. To explore the possible benefits ofc...
متن کاملDiastolic Function in Heart Failure
Heart failure has reached epidemic proportions, and diastolic heart failure or heart failure with preserved ejection fraction (HFpEF) constitutes about 50% of all heart failure admissions. Long-term prognosis of both reduced ejection fraction heart failure and HFpEF are similarly dismal. No pharmacologic agent has been developed that actually treats or repairs the physiologic deficit(s) respons...
متن کاملCoronary magnetic resonance angiography in heterotopic heart transplant recipient.
C oronary allograft vasculopathy remains the main limiting survival factor after heart transplantation and the major cause of mortality after the first year post-transplant, ultimately leading to graft loss. 1 Coronary x-ray angiogra-phy is the clinical gold standard and the most widely used diagnostic technique for coronary allograft vasculopathy in the majority of transplant centers. However,...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1994
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(94)70193-8